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The concomitant use of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors might lead to a rise in methadone plasma concentrations, which could induce potentially fatal respiratory depression. Furthermore, discontinuation of concomitantly employed cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also end in an increase in me